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Similar concerns apply to phosphodiesterase-5 inhibitors (medications like sildenafil) and L-arginine supplements that also influence nitric oxide signaling
However, development was discontinued in 2007 after the largest Phase IIb trial failed to demonstrate statistically significant weight loss compared to placebo
Palatable liquid can be added to feed or administered orally
They neutralise harmful free radicals, which may be generated by environmental factors such as UV radiation, pollution and poor diet
Modulating neurotransmitter activity, which may protect against neurodegenerative disorders
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