taking tirzepatide and not losing weight Why Am I On Why Tirzepatide Isn't Working: 2026

Khoronenkova SV, Dianova II, Ternette N, Kessler BM, Parsons JL, Dianov GL

Tirzepatide is a dual GIP and GLP-1 agonist that generally produces greater weight loss than semaglutide alone

Clin Kidney J 15(8):15931600

The strong effect of these drugs on both diabetes and weight loss has led to a huge rise in global demand, causing supply shortages for the original makers

When patients report a dramatic reduction in opioid cravings from a drug that was prescribed for a different condition (diabetes or obesity), it is unlikely to be a placebo effect because the reduction in cravings was not the goal or an expected impact of the treatment