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Major cardiovascular outcome trials include: LEADER trial (liraglutide): Demonstrated a significant reduction in major adverse cardiovascular events (MACE) in patients with type 2 diabetes and high cardiovascular risk SUSTAIN-6 (semaglutide): Showed reduced cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke REWIND (dulaglutide): Confirmed cardiovascular benefits across a broad patient population SELECT trial (semaglutide): Showed reduced MACE in people with obesity without diabetes, though this evidence is not yet fully incorporated into UK labelling [17] These trials consistently found that the modest heart rate increases observed did not translate into adverse cardiovascular outcomes

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In one study, patients who took tesamorelin had significantly less liver fat compared to those who took a placebo, with a reduction of about 4.1%

Epithalon Studies on Tumor Growth Pathways Rodent experiments have investigated Epithalon in the context of cancer research, with particular attention to its potential modulation of circadian-related genes