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Engineered commensals for targeted nose-to-brain drug delivery

Some people might feel a bit of discomfort, redness, or warmth where the infusion was given

Gln depletion treatment activates FADD and caspase-8-dependent apoptosis involving pro-apoptotic TNF-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) in tumour cells, while metabolic stress induced by glutamine deprivation leads to the downregulation of the GCN2-non-dependent FLICE-inhibitory protein (FLIP), which promotes caspase-8 activation and apoptosis [55]

This work was supported by the Loterie Romande and the Fonds pour la Recherche en Sant du Qubec (SL)

(20) suggested that a lower GSH may be a potential marker of MDD early in the course of the disease