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The primary mechanism involves tyrosinase inhibition, where glutathione binds to copper at the enzymes active sites to reduce melanin synthesis

The co-factor stack compounds this: ALA: Regenerates oxidised glutathione back to active form extends effective activity NAC: Provides cysteine, the rate-limiting precursor for endogenous glutathione synthesis Astaxanthin: UV-protective carotenoid prevents oxidative damage that triggers melanin production Richie et al

Nitric oxide and prostaglandins interact to prevent hepatic damage during murine endotoxemia