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The peptides molecular structure prevents it from crossing the blood-brain barrier and accessing hypothalamic regions responsible for hunger signaling

Ann Intern Med 130(4 Pt 1):301311

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It is distinguished by its ability to activate three physiologically significant receptors simultaneously: the glucagon-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GCGR)