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In our study, FOXO4-DRI selectively induced apoptosis in senescent keloid fibroblasts by promoting the relocation of p53-pS15 from the nucleus to the cytoplasm, exhibiting similar clearance efficiency to that in normal skin fibroblasts
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Effects of tirzepatide versus insulin glargine on kidney outcomes in type 2 diabetes in the SURPASS-4 trial: Post-hoc analysis of an open-label, randomised, phase 3 trial
It produces greater weight loss (approximately 10-12% even in diabetic patients, who typically lose less than non-diabetics), provides excellent blood sugar control (HbA1c reductions of 1.0-1.8 percentage points), and has proven cardiovascular protection (especially important since diabetes increases cardiovascular risk)
