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However, baseline ASCVD or HF showed a statistically significant impact on MACE ( P = 0.0195, I 2 = 0.00%, R 2 = 100%), indicating that these comorbidities fully accounted for the variability in MACE events, while metformin use had a modest effect
Subcutaneous injection of EGCG in mice at doses exceeding 100 mg/kg/day induces severe hepatotoxicity and dose-dependent mortality, with higher concentrations leading to accelerated death
doi: 10.1016/j.jnutbio.2016.10.005 216
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