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Side effects Most common: nausea, vomiting, diarrhea, constipation, abdominal discomfort, headache, fatigue, injection-site reactions
(Brewer et al., 1946
In late 2025, Eli Lilly cut prices on Zepbound single-dose vials to expand obesity treatment options and reduce out-of-pocket burden
Wegovy is called a GLP-1 agonist
The Phase 2 trial of retatrutide (Jastreboff et al., New England Journal of Medicine , 2023) reported that the most common adverse effects were gastrointestinal in nature (nausea, vomiting, diarrhoea), consistent with the GLP-1 receptor agonist class
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