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Fuentes bibliogrficas Utilizadas Gmez-Campos, R (2009)
J Endocrinol 243(2):149160 Willard FS, Douros JD, Gabe MB, Showalter AD, Wainscott DB, Suter TM et al (2020) Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist
JAAD Case Rep
Tanday et al., (2022) have since described a role for Y1-R agonism in inducing periods of -cell rest that, when combined with GLP-1R agonism, proved beneficial in obesity-driven models of diabetes
This leads to a reduction in TCA cycle gene expression and oxygen consumption as well as an increase in lactate production and cell proliferation 89
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