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For rigorous synergy evaluation, researchers should use full concentration-response curves for each peptide alone and a two-dimensional concentration matrix of the combination, pre-define the additivity model (e.g., Bliss independence or Loewe additivity), state the calculation method, and perform independent biological replicates

* The results were based on an open label 100­-person human study conducted over six months with no caloric restrictions or exercise requirement

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