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Most RCTs enrolled heterogenous populations, including patients with hypoactive and/or hyperactive delirium, patients already experiencing sleep disruption, making it unclear whether there is a specific subgroup that could benefit from melatonin administration

Lewis KA, Tollefsbol TO (2016) Regulation of the telomerase reverse transcriptase subunit through epigenetic mechanisms

DEREK MUNRO: So you can get performance enhancement as low as I think some people was like a milligram per kilogram

These can inform B12 deficiency likelihood