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Reports that DPP-4 may be associated with glucagon in the secretory granules of the pancreatic -cell first emerged in 1993, when positive staining in pig islets was shown using immunohistochemical and enzyme histochemical techniques (96), but the pancreatic localization of DPP-4 has also been unequivocally demonstrated more recently using molecular biological techniques (9799)
Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23
Interaction with NMDA and AMPA Receptors DSIP may modulate glutamatergic signaling , including NMDA and AMPA receptors, which are important in memory, stress response, and circadian regulation
Particularly, the background anti-diabetic agents, lipid-lowering drugs, antiaggregants, and antihypertensives may affect cardiovascular events
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