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Microarray analysis of the cellular pathways involved in the adaptation to and progression of motor neuron injury in the SOD1 G93A mouse model of familial ALS

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Only three glycosylation sites were found across the 93 PsomGSTs

Treatment with either lovastatin or lapaquistat appeared to reduce squalene levels even further, as they both target enzymes upstream of squalene synthesis, while conversely, NB-598 treatment produced at least a 100-fold increase in squalene levels in host cells (Fig 3D, right)