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Neither route is inherently superioreach serves distinct research applications that the other cannot address
Retatrutide also reduced pain in patients with knee osteoarthritis, with Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain scores dropping by as much as 4.5 points, a 75.8% reduction with the 9 mg dose, compared with a 2.4 point (40.3%) reduction for placebo
The drug reaches its maximum concentration, known as Cmax, somewhere between 8 and 72 hours after injection
Plans may differentiate by indication: a policy might cover semaglutide for T2D with minimal restrictions, but treat a Wegovy prescription with the same molecule as off-label (for weight) and therefore require stricter criteria
NCT05765643
