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From thymosin alpha-1 and its capacity to rebalance T-cell populations, to KPV and its targeted anti-inflammatory action through NF-kB inhibition, to experimental peptides like P140/Lupuzor that have reached Phase III clinical trials specifically for lupus, the landscape of peptide-based immune modulation is expanding rapidly

Functionally, this predicted cleavage site is only 5 residues from the C terminal of TXNRD1, and would result in removal of the C-terminal redox center of TXNRD1 (AGCUG), making the enzyme incapable of regenerating reduced thioredoxin

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Front Endocrinol (Lausanne) (2019) 10:155

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