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It is possible that these variants have impaired folding and localisation, although R169W has previously been shown to localise normally to the membrane 53
These transcriptional effects potentially encompass a wide spectrum of biological processes, including tissue remodeling, antioxidant defenses, anti-inflammatory responses, pain modulation, anxiety alleviation, angiogenesis, nerve outgrowth, and anti-cancer actions
Furthermore, studies have shown that following the consumption of ellagitannin-rich pomegranate extract, high concentrations of UA are detected in the prostate, gut, and colon of prostate cancer model mice, whereas elevated levels of UA-sulfate and UA-glucuronide are detected in the liver and kidneys (29)
Daglis, S
Feng L, Liang L, Zhang S, Yang J, Yue Y, Zhang X
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