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The inflammatory mechanism plays a role in the development of epilepsy associated with T2DM, as inflammatory biomarkers such as interleukins (IL-1, IL-6, and IL-8), tumor necrosis factor-, high-mobility group box 1, and toll-like receptors are elevated in both epileptic seizures and T2DM (91)
In accordance, treatment of mouse 32D myeloid progenitor and human HEK-293T cells with JMF4073 for 6 h significantly reduced the cellular level of TTP and dCTP (Fig
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