Chronic high-dose pyridoxine can cause sensory neuropathymanifesting as numbness, tingling, or gait instabilityemphasizing the need for appropriate dosing and periodic reassessment
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In the liver, the net result (due to increased acetyl-CoA levels) is the production of ketone bodies (see below)
It's being investigated to treat inflammatory bowel diseases, including Crohn's and ulcerative colitis
Clinically, this manifests as peripheral neuropathy, characterized by numbness, painful tingling, burning sensations in the extremities, and eventual loss of motor function