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Data from the LEADER CVOT [31] were used to develop a CV risk score to distribute subjects according to CV risk

Clinical trials included participants up to age 75 with favorable safety results, and no specific age cutoff exists where GLP-1 medications become unsafe

Other identified topics reflected the positive impact of these medications for weight loss on motivation levels and mental health associated with specific obesity-related comorbidities (topics 64, 114)

Some clinicians may recommend a dose as high as 400 mcg per day

Glucagon receptor activation can alter vascular tone and inflammatory signalling, and GIP receptor stimulation has been shown to modulate immune responses in some preclinical models