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GLP-1 Body Composition Changes What Trials Show About Lean Mass Clinical trials of semaglutide and tirzepatide consistently demonstrate that effective GLP-1 weight loss reduces both fat and lean mass , with fat making up the majority of the loss (DXA substudies)
For patients with type 2 diabetes, tirzepatide improves glycemic control
While these studies provide valuable information on important outcomes, such as weight loss and safety, future study is needed to further evaluate long-term effects, cardiovascular outcomes, and patient-centered endpoints
Benninger, M
If the jump from 0.5mg to 1mg feels too aggressive, a provider can help you adjust
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