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In addition, we tested for co-localization with expression quantitative trait loci in the locus, and identified none that colocalized with the GWAS signal (Supplementary Information)
Currently, there is not enough high-quality clinical evidence to support the use of BPC-157 for weight management or fat loss in humans
The study found that the combination therapy resulted in a significant mean body weight reduction of 20.4% compared to 3.0% with placebo, and was superior to both monotherapies
Given that amylin signalling is a key therapeutic target for next-generation weight-loss drugs, amylin receptor agonists such as pramlintide, cagrilintide and KBP-066 also warrant consideration as to metabolism and detection strategies in sports drug testing programs
