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Because GLP-1s impact the parts of the brain involved with reward, researchers began to wonder if they could reduce addictive behaviors

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The patients most likely to show a divergent psychiatric response to GLP-1 therapy those with comorbid SUD, prior mood episode history, or active anhedonia at baseline are exactly the patients who get excluded for psychiatric instability. The result is a Phase 3 dataset that proves efficacy in a population cleaner than anyone sitting in an actual psychiatric clinic

[5] Anti-inflammatory and antioxidant effects