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doi: 10.3390/nu12051325

Stay Hydrated Drinking plenty of water helps your body adjust to the treatment and reduces the chances of experiencing side effects like nausea

Individuals with liver disease, severe kidney impairment, or a personal history of medullary thyroid cancer should not use semaglutide, regardless of nausea management strategies

If you are also taking related medications, see our companion guides on Mounjaro vs Ozempic, Zepbound vs Wegovy, and what to eat on Ozempic

While the results of this article do not exclude a direct action of metformin in the liver, they suggest that the first site of metformin action is the gut, via gut-hepatic crosstalk, and that it may play a role in the control of hepatic glucose production, integrating the site and mechanism of metformin action