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Both peptides are not approved for routine human use (sold for research purposes) and are banned in competitive sports [10]
In rat pinealocytes (the melatonin-producing cells of the pineal gland), Epitalon was shown to upregulate both AANAT (arylalkylamine N-acetyltransferase, the rate-limiting enzyme in melatonin production) and pCREB (a transcription factor involved in melatonin gene expression)
Dihexa acts as an analog of angiotensin IV, a compound known to stimulate brain-derived neurotrophic factor (BDNF)
The compound's sleep-promoting and related general physiological effects after intraventricular (brain), intravenous, and intraperitoneal application in different mammalian species have since been confirmed
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