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Description

Relevant preclinical studies have demonstrated that Ex-4, by acting on GLP-1R, inhibits the PI3K/Akt signaling pathway and increases the expression of Caspase-3 and E-cadherin, thereby promoting apoptosis in human ovarian cancer cells and reducing their metastasis [72]

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This is again opposed to our observation of LSD1 preserving glutathione levels, however no LSD1 inhibitors were used in their investigation so it cannot be said if binding sites on LSD1 play a role or if the differential response is due to tissue type

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