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MET forms clusters at excitatory synapses in relatively mature cultured hippocampal neurons and co-localizes with the post-synaptic protein PSD-95 and with the glutamatergic N-methyl-D-aspartate (NMDA) receptor subunit GluN2B ( in vitro and in vivo methods to examine how altered MET signaling impacts synaptic development, observing an opposite effect on neuronal morphology in a stage-dependent way

\Favorable Tolerability: Mostly GI-related adverse events with relatively low discontinuation

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