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The intricacy and multidimensionality of the mechanisms underlying brain diseases demands such an adequate analytical and generalizing tool allowing taking into account the multifactorial nature of a brain disease, involvement of cross-signaling and interaction between different brain regions and peripheral organs and tissues [85].The principal cause of many brain diseases is insufficient insulin sensitivity (insulin resistance)
Published clinical trial data has shown progressively greater effects with each successive generation, suggesting that multi-target approaches may offer advantages in metabolic research
"ICH Q7: Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients." ICH Harmonised Guidelines, 2000.
In reality, its far more complex
Mice were randomized and stratified to treatment based on baseline mean steatosis, lobular inflammation, fibrosis stage, and % area of fibrosis (PSR)
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