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Cohen, T.V
REMODEL: a mechanistic trial evaluating the effects of semaglutide on the kidneys in people with type 2 diabetes and chronic kidney disease
Results from initial clinical trials suggest that GLP-1 medications promote smoking abstinence, reduce nicotine craving and withdrawal, and prevent weight gain that frequently occurs with smoking cessation
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In the present study, we found that cardiac mitophagy dysfunction induced by pressure overload can activate NLRP3 inflammasome, and lead to cardiac hypertrophy, and improving mitophagy by semaglutide could suppress the activation of NLRP3 inflammasome to alleviate cardiac hypertrophy
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