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Name: glp-1 drugs retatrutide The experimental drug 'reta' also improved blood sugar and heart health metrics. But side effects led more than 1 in 10 to drop out of trials early: https://bit.ly/4x6Aexb Retatrutide - Wikipedia
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Beyond glycaemic control, GLP-1 medications have a significant effect on appetite regulation

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However, there has been less emphasis on thiazide-like diuretics, despite evidence that both chlorthalidone and indapamide may offer better metabolic outcomes compared to hydrochlorothiazide (Kostis et al., 1997