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It acts as a substrate linker for the interaction of Cullin 3 (CUL3)-dependent E3 ubiquitin ligase complex [119], with NRF2 leading to continuous ubiquitination and proteasomal degradation of NRF2 [120], thus representing the main negative regulator of NRF2 activity
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Still others reported cognitive benefits like decreased anxiety and brain fog and improved focus
The prescription requirement exists because these medications carry real risks, including potential pancreatitis, gallbladder disease, thyroid concerns, and serious gastrointestinal side effects
10.1016/j.jcmgh.2018.04.003 239
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