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Nausea and vomiting : This was the most frequently reported side effect across various study groups Withdrawal due to side effects : In the group receiving the highest dose, four out of eight patients discontinued the study due to these mild gastrointestinal issues Pancreatic concerns A notable concern that appeared during the trials was the increase of pancreatic enzymes, which can show pancreatic stress or damage

The GIP receptor pathway Glucose-dependent insulinotropic polypeptide is secreted by K-cells in the proximal small intestine

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In 2009, modified fasting therapy was initially applied as a therapeutic option for the management of overweight, obesity and MetS in South China [3]