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Key points Vascular damage in chronic kidney disease (CKD) increases the risk of stroke and cognitive impairment, with faster CKD progression linked to cerebral damage, subcortical infarcts and bloodbrain barrier disruption

In two isolated cases reported two women in Seattle (one with cancer) died due to the enemas removing potassium from the body leading to serious electrolyte imbalance

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Many of them are gastrointestinal (related to the stomach and intestines) in nature

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