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MASH is very common and represents a major public health issue because it increases the risk of liver-related complications, such as cirrhosis and hepatocellular carcinoma, as well as cardiovascular events, chronic kidney disease, type 2 diabetes, extrahepatic cancers, and severe infections

Participants receiving the 5mg dose achieved an average 16.0% body weight reduction

Estillore et al., 2017

Most research involves short-term endpoints

Kidney Function NSAIDs can reduce blood flow to the kidneys, potentially causing kidney damage, especially in people who are older, dehydrated, or have pre-existing kidney problems