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As established earlier, the menopausal transition is associated with a shift toward chronic low-grade inflammation, driven partly by the loss of estrogen's anti-inflammatory signaling and partly by the accumulation of metabolically active visceral fat

It enables investigation of appetite regulation, glucose homeostasis, and energy balance through integrated endocrine signaling across coordinated metabolic receptor pathways

Melanotan-2 remains the more pharmacologically diverse compound with broader melanocortin effects including tanning, but its lack of regulatory approval and wider side effect profile reflect its status as an unrefined parent compound

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