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J Biol Chem 273: 60096012 Zhang K, Kaufman RJ (2004) Signaling the unfolded protein response from the endoplasmic reticulum

GLP-1 plays several important roles in metabolic health

An apparent paradox is that whereas GLP-1 increases glucose-stimulated insulin secretion in the isolated pancreas fulfilling the definition of an incretin but it lowers insulin secretion in physiologically relevant conditions [6, 10, 18]

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