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The receptors share the IRS-1, PI3K/Akt and Ras/MAPK branches, so a phosphorylation readout alone will not discriminate
In adipose tissue, HIF activation can improve IR by stimulating the thermogenic function of brown adipose tissue (BAT) by regulating mitochondrial biogenesis and glycolysis
In terms of mechanisms, NAD+ supports DNA repair by activating enzymes known as sirtuins, which help maintain genomic stability
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