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44 An open-label, uncontrolled trial in 51 patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) found improvements in 34 patients after 3 months of supplementation with hydroxo-B12, 10 000 mcg twice per week as nasal drops

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Others target the exact side effects that drive people to quit their medication

The alcohol you consume stays in your bloodstream longer because the primary metabolic pathway is suppressed