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Surprisingly, we found that Ckmt1 -KO mice treated with SANA showed a ~50% increase in mortality rate after 1 week of treatment (no mortality occurred in wild-type (WT) mice), an effect that was rescued when Ckmt1 -KO mice were acclimatized at thermoneutrality during the treatment with SANA (Fig

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The GLP-1 receptor agonist liraglutide inhibits progression of vascular disease via effects on atherogenesis, plaque stability and endothelial function in an ApoE/ mouse model

Syngal S, Coakley EH, Willett WC, Byers T, Williamson DF, Colditz GA