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Pharmacologic inhibition of VDAC oligomerization with VBIT-4 reduced mtDNA release and attenuated interferon linked pathology in a lupus model, providing proof of principle that restricting mitochondrial danger signals escape can indirectly dampen downstream organelle coupled inflammatory signaling, including cGAS-dependent STING signaling (168)

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Archived from the original on 27 November 2019

In obesity care, the same agents are framed around weight reduction, cardiometabolic risk improvement, and, increasingly, quality of life

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