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Imbriani et al., 2018), as well as in related neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (Taoufik et al., 2018
Hippo/Mst signaling couples metabolic state and immune function of CD8+ dendritic cells
Synaptic Vesicle 2A Positron Emission Tomography Tracers in Animal Models of Epilepsy Even though the development of SV2A tracers was motivated by epilepsy research, only three articles have been published to date in this area: two clinical proof-of-concept studies about the ability of [ 11 C]UCB-J radiotracer to detect a decrease in synaptic density in patients with temporal lobe epilepsy and unilateral mesial temporal sclerosis (Finnema et al., 2016, 2020), and one preclinical study exploring in vivo changes in SV2A during the development of temporal lobe epilepsy (Serrano et al., 2020)
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