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Hepatocytes have a reduced capacity to eliminate ammonia through the urea cycle, leading to hyperammonemia that stimulates glutamine synthesis in extrahepatic tissues (muscle, brain, heart, and lungs)

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Nat Med 28:911923 Correia AS, Vale N (2022) Tryptophan metabolism in depression: a narrative review with a focus on serotonin and kynurenine pathways

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Predictive and prognostic impact of ferroptosis-related genes ACSL4 and GPX4 on breast cancer treated with neoadjuvant chemotherapy

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