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The mechanisms of acute interstitial nephritis in the era of immune checkpoint inhibitors in melanoma

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CD8+ T cells produce perforin and granzyme to provide protection against viral infection, resulting in a decline in the viral load

In contrast, early studies suggested that activated T cells adopt a glycolysis-centric phenotype, with a subsequent return to oxidative metabolism and FAO in memory T cells ( in vivo do not cycle carbons from glucose into lactate but rather transition these glucose carbons into intermediates of the TCA cycle (122)