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P = 0.078

However, the nature of optimal dietary support may differ between the two compounds

Network meta-analyses confirm Retatrutides edge in total weight loss but highlight Tirzepatides superior profile for glycemic control, insulin resistance reversal, and systemic health benefits

Ozempic is the stronger choice for weight loss (up to 15% of body weight) and A1C reduction (-1.8%), while Farxiga excels in heart failure prevention (-30% hospitalizations) and chronic kidney disease protection (-39% progression)