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In subjects with severe RI, the mean exposure of semaglutide was 22% higher than in subjects with normal renal function, and the 95% confidence interval (1.021.47) for the ratio exceeded the pre-specified limits (0.701.43)
At the 10mg/ml concentration, the difference between 25 units and 26 units is 0.1mg, a 4% dosing error on a 2.5mg dose
However, questions arise about their impact on muscle mass
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