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But a strong growth signal cuts both ways, and IGF-1 LR3 carries real, specific risks: It can act a bit like insulin and lower blood sugar, which can be dangerous (low blood sugar can cause shakiness, confusion, or worse)

If the liver runs out of glutathione, it can become sluggish, which may indirectly lead to difficulties in managing blood sugar levels

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Looking forward, a comprehensive understanding of DDR pathway rewiring, coupled with integrated omics-based profiling and network-level vulnerability mapping, will be pivotal