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domperidone (where available) When to escalate: Burps persisting beyond 8 weeks despite OTC management, or accompanied by significant nausea, vomiting, or weight loss beyond expected When to discontinue semaglutide: Gastroparesis confirmed on gastric emptying study, or intractable symptoms affecting oral intake and quality of life Why Semaglutide Causes Sulfur Burps: The Mechanism You Need to Understand Before Choosing a Drug Semaglutide activates GLP-1 receptors in the enteric nervous system and the vagal afferent pathways, producing a pronounced reduction in gastric emptying rate
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The REDEFINE trials showed the combination produces approximately 22.7% body weight reduction, significantly more than either peptide alone
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