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Providers should prioritize SGLT2 inhibitors in patients with type 2 diabetes to prevent progression to kidney failure
GIP receptor activation appears to amplify the metabolic benefits beyond what GLP-1 agonism alone can achieve, which is why tirzepatide consistently outperforms semaglutide in head-to-head comparisons
Later, dipeptidyl peptidase-4 (DPP-4) was reported to rapidly remove the N-terminal diamino acid peptide of GLP-1 by recognizing alanine and proline at the penultimate position [4]
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The medication slows gastric emptying and affects gastrointestinal motility, commonly causing nausea, diarrhoea, vomiting, and constipation
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