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Remember that semaglutide ( Ozempic/Wegovy ) and tirzepatide ( Mounjaro/Zepbound ) work slightly differently, and switching between them may yield better results

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However, the substantial weight loss they facilitate does result in some loss of lean body mass, as occurs with any significant weight reduction

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This is supported by the finding that the concentration of semaglutide is reduced dramatically in the stomach cells bordering the tablet's physical location