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Both semaglutide and tirzepatide have been approved for chronic weight management in adults with obesity or weight-related health conditions who do not have diabetes

A new quintuple agonist tested in obese, insulin-resistant mice has shown superior efficacy in reducing body weight, improving glycemia, and enhancing lipid metabolism compared with GLP-1/GIP duals, pan-PPAR alone, or even combinations of the two

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Clinical Evidence and Efficacy Comparison of Common Non-GLP-1 Agents Clinical trial data shows varying weight loss outcomes across non-GLP-1 options